主讲人:李劲松 研究员 中国科学院院士




李劲松院士从事干细胞与胚胎发育相关研究。率领团队建立了小鼠孤雄单倍体胚胎干细胞(即“类精子干细胞”),证明其能代替精子使卵子受精产生健康小鼠(即“半克隆技术”),并利用类精子干细胞携带CRIPSR-Cas9文库实现了小鼠个体水平的遗传筛选;提出并推动基于类精子干细胞技术的基因组标签计划。研究成果2011年和2012年入选“中国科学十大进展”。以第一作者或通讯作者身份在Cell, Nature, Cell Stem Cell, Nature Cell Biology等杂志发表60余篇研究论文。

Brief Introduction of Professor Jinsong Li

Professor Jinsong Li is a principle investigator (PI) at Center for Excellence in Molecular Cell Science (CAS). He is a member of Chinese Academy of Sciences. Dr. Li obtained his PhD degree from Institute of Zoology, Chinese Academy of Sciences, in 2002 and followed by postdoctoral training at Rockefeller University before joining Shanghai Institute of Biochemistry and Cell Biology (SIBCB) in 2007. His research mainly focuses on stem cells and embryonic development. He has made fundamental contributions to the establishment of androgenetic haploid embryonic stem cells (also termed “sperm-like stem cells” or “artificial spermatids”) that can be used as sperm replacement for efficient production of semi-cloned mice (so called semi-cloning (SC) technology). Dr. Li has made great efforts to promote the applications of SC technology and shown that it can be used as a unique tool for genetic analyses in mice, including efficient generation of mouse models carrying defined point mutations related to human developmental defects; one-step generation mouse models that mimic multiple genetic defects in human diseases; and medium-scale targeted screening of critical genes or critical nucleotides of a specific gene involved in a developmental process. Most recently, Dr. Li launched and is promoting a huge project to tag every protein in mice based on sperm-like stem cell-mediated SC technology (genome tagging project, GTP), which may enable the precise description of protein expression and localization patterns, and protein–protein, protein–DNA and protein–RNA interactions in development/ aging, physiological and pathological conditions.

发布单位: 科学技术发展研究院

发布日期: 2022-09-19